基因注释：DFFB

官方名称：DNA fragmentation factor subunit beta

功能摘要：Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene but the biological validity of some of these variants has not been determined. [provided by RefSeq, Sep 2013].

• RBFOX2 综合评分: 0.474 · 证据 2 条
• HNRNPC 综合评分: 0.448 · 证据 2 条
• PTBP1 综合评分: 0.444 · 证据 2 条
• HNRNPK 综合评分: 0.398 · 证据 2 条
• HNRNPL 综合评分: 0.398 · 证据 2 条
• HNRNPM 综合评分: 0.350 · 证据 2 条
• EWSR1 综合评分: 0.250 · 证据 2 条
• RBM10 综合评分: 0.250 · 证据 2 条
• RBM15 综合评分: 0.250 · 证据 2 条
• Srsf1 综合评分: 0.248 · 证据 1 条
• Tardbp 综合评分: 0.248 · 证据 1 条
• Rbmx 综合评分: 0.224 · 证据 1 条
• PRPF8 综合评分: 0.200 · 证据 1 条
• Ptbp2 综合评分: 0.200 · 证据 1 条
• CSTF2T 综合评分: 0.162 · 证据 2 条
• SAFB2 综合评分: 0.162 · 证据 1 条
• CPSF6 综合评分: 0.150 · 证据 2 条
• CPSF7 综合评分: 0.150 · 证据 2 条
• CSTF2 综合评分: 0.150 · 证据 2 条
• GRSF1 综合评分: 0.150 · 证据 2 条

该基因暂无关联疾病记录