🧬 基因注释：DHFR
📝 官方信息
官方名称：dihydrofolate reductase
功能摘要：Dihydrofolate reductase converts dihydrofolate into tetrahydrofolate, a methyl group shuttle required for the de novo synthesis of purines, thymidylic acid, and certain amino acids. While the functional dihydrofolate reductase gene has been mapped to chromosome 5, multiple intronless processed pseudogenes or dihydrofolate reductase-like genes have been identified on separate chromosomes. Dihydrofolate reductase deficiency has been linked to megaloblastic anemia. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2014].
🎯 作为靶基因的剪接因子
- HNRNPA1 综合评分: 0.510 · 证据 2 条
- HNRNPC 综合评分: 0.510 · 证据 2 条
- FUS 综合评分: 0.506 · 证据 1 条
- fus 综合评分: 0.506 · 证据 1 条
- HNRNPM 综合评分: 0.494 · 证据 2 条
- HNRNPF 综合评分: 0.474 · 证据 2 条
- HNRNPH1 综合评分: 0.412 · 证据 2 条
- Srsf3 综合评分: 0.398 · 证据 1 条
- CELF2 综合评分: 0.398 · 证据 2 条
- HNRNPL 综合评分: 0.362 · 证据 2 条
- SRSF2 综合评分: 0.362 · 证据 1 条
- HNRNPA2B1 综合评分: 0.350 · 证据 2 条
- MBNL1 综合评分: 0.350 · 证据 2 条
- QKI 综合评分: 0.350 · 证据 1 条
- EWSR1 综合评分: 0.312 · 证据 2 条
- RBM10 综合评分: 0.312 · 证据 2 条
- TIA1 综合评分: 0.312 · 证据 1 条
- ACIN1 综合评分: 0.310 · 证据 2 条
- HNRNPD 综合评分: 0.300 · 证据 2 条
- HNRNPK 综合评分: 0.300 · 证据 2 条
🏥 关联疾病
该基因暂无关联疾病记录