🧬 基因注释：DLK1
📝 官方信息
官方名称：delta like non-canonical Notch ligand 1
功能摘要：This gene encodes a transmembrane protein that contains multiple epidermal growth factor repeats that functions as a regulator of cell growth. The encoded protein is involved in the differentiation of several cell types including adipocytes. This gene is located in a region of chromosome 14 frequently showing unparental disomy, and is imprinted and expressed from the paternal allele. A single nucleotide variant in this gene is associated with child and adolescent obesity and shows polar overdominance, where heterozygotes carrying an active paternal allele express the phenotype, while mutant homozygotes are normal. [provided by RefSeq, Nov 2015].
🎯 作为靶基因的剪接因子
- HNRNPK 综合评分: 0.398 · 证据 2 条
- RBFOX2 综合评分: 0.362 · 证据 2 条
- HNRNPM 综合评分: 0.350 · 证据 2 条
- TIA1 综合评分: 0.312 · 证据 1 条
- FUS 综合评分: 0.300 · 证据 1 条
- HNRNPL 综合评分: 0.300 · 证据 2 条
- PTBP1 综合评分: 0.300 · 证据 2 条
- SRSF9 综合评分: 0.300 · 证据 1 条
- fus 综合评分: 0.300 · 证据 1 条
- NOVA1 综合评分: 0.298 · 证据 2 条
- PCBP1 综合评分: 0.298 · 证据 2 条
- PRPF8 综合评分: 0.298 · 证据 1 条
- Nova2 综合评分: 0.262 · 证据 1 条
- PCBP2 综合评分: 0.262 · 证据 1 条
- AQR 综合评分: 0.248 · 证据 1 条
- PRPF4 综合评分: 0.212 · 证据 1 条
- SF3A3 综合评分: 0.200 · 证据 1 条
- PABPC4 综合评分: 0.150 · 证据 2 条
- Tardbp 综合评分: 0.150 · 证据 1 条
- U2af1 综合评分: 0.150 · 证据 1 条
🏥 关联疾病
该基因暂无关联疾病记录