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🧬 基因注释:DAZAP1

📝 官方信息

官方名称:DAZ associated protein 1

功能摘要:In mammals, the Y chromosome directs the development of the testes and plays an important role in spermatogenesis. A high percentage of infertile men have deletions that map to regions of the Y chromosome. The DAZ (deleted in azoospermia) gene cluster maps to the AZFc region of the Y chromosome and is deleted in many azoospermic and severely oligospermic men. It is thought that the DAZ gene cluster arose from the transposition, amplification, and pruning of the ancestral autosomal gene DAZL also involved in germ cell development and gametogenesis. This gene encodes a RNA-binding protein with two RNP motifs that was originally identified by its interaction with the infertility factors DAZ and DAZL. Two isoforms are encoded by transcript variants of this gene. [provided by RefSeq, Jul 2008].

🎯 作为靶基因的剪接因子
  • HNRNPM 综合评分: 0.474 · 证据 2 条
  • HNRNPC 综合评分: 0.412 · 证据 2 条
  • QKI 综合评分: 0.412 · 证据 1 条
  • HNRNPK 综合评分: 0.398 · 证据 2 条
  • RBFOX2 综合评分: 0.362 · 证据 2 条
  • SRSF2 综合评分: 0.362 · 证据 1 条
  • SRSF9 综合评分: 0.362 · 证据 1 条
  • Srsf3 综合评分: 0.362 · 证据 1 条
  • HNRNPA1 综合评分: 0.350 · 证据 2 条
  • HNRNPA2B1 综合评分: 0.350 · 证据 2 条
  • HNRNPH1 综合评分: 0.350 · 证据 2 条
  • MBNL1 综合评分: 0.350 · 证据 2 条
  • RBM10 综合评分: 0.312 · 证据 2 条
  • TIA1 综合评分: 0.312 · 证据 1 条
  • Srsf1 综合评分: 0.310 · 证据 1 条
  • Rnps1 综合评分: 0.306 · 证据 1 条
  • FUS 综合评分: 0.300 · 证据 1 条
  • HNRNPL 综合评分: 0.300 · 证据 2 条
  • HNRNPU 综合评分: 0.300 · 证据 2 条
  • KHSRP 综合评分: 0.300 · 证据 2 条
🏥 关联疾病
neurodegenerative disease
中关联 (0.430)
monoclonal B-cell lymphocytosis
低关联 (0.111)
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🔗 外部数据库链接