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🧬 基因注释:EIF4A3

📝 官方信息

官方名称:eukaryotic translation initiation factor 4A3

功能摘要:This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene is a nuclear matrix protein. Its amino acid sequence is highly similar to the amino acid sequences of the translation initiation factors eIF4AI and eIF4AII, two other members of the DEAD box protein family. [provided by RefSeq, Jul 2008].

🎯 作为靶基因的剪接因子
  • HNRNPC 综合评分: 0.556 · 证据 2 条
  • RBFOX2 综合评分: 0.444 · 证据 2 条
  • HNRNPA2B1 综合评分: 0.412 · 证据 2 条
  • FUS 综合评分: 0.362 · 证据 1 条
  • fus 综合评分: 0.362 · 证据 1 条
  • HNRNPH1 综合评分: 0.350 · 证据 2 条
  • Rnps1 综合评分: 0.342 · 证据 1 条
  • HNRNPU 综合评分: 0.300 · 证据 2 条
  • KHSRP 综合评分: 0.300 · 证据 2 条
  • PTBP1 综合评分: 0.300 · 证据 2 条
  • SRSF2 综合评分: 0.300 · 证据 1 条
  • SRSF3 综合评分: 0.300 · 证据 1 条
  • Srsf2 综合评分: 0.300 · 证据 1 条
  • Srsf3 综合评分: 0.300 · 证据 1 条
  • PRPF8 综合评分: 0.298 · 证据 1 条
  • Tardbp 综合评分: 0.294 · 证据 1 条
  • EWSR1 综合评分: 0.250 · 证据 2 条
  • RBM10 综合评分: 0.250 · 证据 2 条
  • RBM15 综合评分: 0.250 · 证据 2 条
  • RBM39 综合评分: 0.250 · 证据 2 条
🏥 关联疾病
Richieri Costa-Pereira syndrome
高关联 (0.774)
dengue disease
中关联 (0.462)
Intellectual disability
低关联 (0.370)
clubfoot
低关联 (0.370)
cleft palate
低关联 (0.370)
Cleft mandible
低关联 (0.370)
Short stature
低关联 (0.370)
microtia
低关联 (0.370)
Pierre-Robin sequence
低关联 (0.370)
neurodegenerative disease
低关联 (0.219)
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🔗 外部数据库链接