🧬 基因注释：EIF4G2
官方名称：eukaryotic translation initiation factor 4 gamma 2
功能摘要：Translation initiation is mediated by specific recognition of the cap structure by eukaryotic translation initiation factor 4F (eIF4F), which is a cap binding protein complex that consists of three subunits: eIF4A, eIF4E and eIF4G. The protein encoded by this gene shares similarity with the C-terminal region of eIF4G that contains the binding sites for eIF4A and eIF3; eIF4G, in addition, contains a binding site for eIF4E at the N-terminus. Unlike eIF4G, which supports cap-dependent and independent translation, this gene product functions as a general repressor of translation by forming translationally inactive complexes. In vitro and in vivo studies indicate that translation of this mRNA initiates exclusively at a non-AUG (GUG) codon. Alternatively spliced transcript variants encoding different isoforms of this gene have been described. [provided by RefSeq, Jul 2008].
- FUS 综合评分: 0.514 · 证据 1 条
- RBFOX2 综合评分: 0.514 · 证据 2 条
- fus 综合评分: 0.514 · 证据 1 条
- HNRNPC 综合评分: 0.510 · 证据 2 条
- Tardbp 综合评分: 0.486 · 证据 1 条
- HNRNPA2B1 综合评分: 0.412 · 证据 2 条
- HNRNPM 综合评分: 0.412 · 证据 2 条
- MBNL2 综合评分: 0.386 · 证据 1 条
- KHSRP 综合评分: 0.362 · 证据 2 条
- PTBP1 综合评分: 0.362 · 证据 2 条
- Srsf2 综合评分: 0.362 · 证据 1 条
- Srsf3 综合评分: 0.362 · 证据 1 条
- ELAVL3 综合评分: 0.358 · 证据 1 条
- HNRNPA1 综合评分: 0.350 · 证据 2 条
- HNRNPH1 综合评分: 0.350 · 证据 2 条
- MBNL1 综合评分: 0.350 · 证据 2 条
- QKI 综合评分: 0.350 · 证据 1 条
- U2af2 综合评分: 0.336 · 证据 1 条
- NOVA1 综合评分: 0.324 · 证据 2 条
- PCBP2 综合评分: 0.324 · 证据 1 条
该基因暂无关联疾病记录