基因注释：F3
官方名称：coagulation factor III, tissue factor
功能摘要：This gene encodes coagulation factor III which is a cell surface glycoprotein. This factor enables cells to initiate the blood coagulation cascades, and it functions as the high-affinity receptor for the coagulation factor VII. The resulting complex provides a catalytic event that is responsible for initiation of the coagulation protease cascades by specific limited proteolysis. Unlike the other cofactors of these protease cascades, which circulate as nonfunctional precursors, this factor is a potent initiator that is fully functional when expressed on cell surfaces, for example, on monocytes. There are 3 distinct domains of this factor: extracellular, transmembrane, and cytoplasmic. Platelets and monocytes have been shown to express this coagulation factor under procoagulatory and proinflammatory stimuli, and a major role in HIV-associated coagulopathy has been described. Platelet-dependent monocyte expression of coagulation factor III has been described to be associated with Coronavirus Disease 2019 (COVID-19) severity and mortality. This protein is the only one in the coagulation pathway for which a congenital deficiency has not been described. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Aug 2020].
- HNRNPA2B1 综合评分: 0.474 · 证据 2 条
- HNRNPC 综合评分: 0.448 · 证据 2 条
- QKI 综合评分: 0.412 · 证据 1 条
- MBNL1 综合评分: 0.350 · 证据 2 条
- SRSF3 综合评分: 0.300 · 证据 1 条
- ELAVL3 综合评分: 0.296 · 证据 1 条
- CSTF2 综合评分: 0.274 · 证据 2 条
- YBX1 综合评分: 0.260 · 证据 1 条
- RBM39 综合评分: 0.250 · 证据 2 条
- PRPF8 综合评分: 0.200 · 证据 1 条
- CSTF2T 综合评分: 0.162 · 证据 2 条
- Tra2b 综合评分: 0.162 · 证据 1 条
- U2af2 综合评分: 0.162 · 证据 1 条
- UPF1 综合评分: 0.162 · 证据 1 条
- ACIN1 综合评分: 0.150 · 证据 2 条
- AQR 综合评分: 0.150 · 证据 1 条
- MSI1 综合评分: 0.150 · 证据 1 条
- Tardbp 综合评分: 0.150 · 证据 1 条
- U2af1 综合评分: 0.150 · 证据 1 条
- CPSF3 综合评分: 0.100 · 证据 1 条
该基因暂无关联疾病记录