🧬 基因注释：FUS
📝 官方信息
官方名称：FUS RNA binding protein
功能摘要：This gene encodes a multifunctional protein component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complex. The hnRNP complex is involved in pre-mRNA splicing and the export of fully processed mRNA to the cytoplasm. This protein belongs to the FET family of RNA-binding proteins which have been implicated in cellular processes that include regulation of gene expression, maintenance of genomic integrity and mRNA/microRNA processing. Alternative splicing results in multiple transcript variants. Defects in this gene result in amyotrophic lateral sclerosis type 6. [provided by RefSeq, Sep 2009].
🎯 作为靶基因的剪接因子
- HNRNPC 综合评分: 0.474 · 证据 2 条
- Srsf3 综合评分: 0.424 · 证据 1 条
- FUS 综合评分: 0.414 · 证据 1 条
- Fus 综合评分: 0.414 · 证据 1 条
- fus 综合评分: 0.414 · 证据 1 条
- HNRNPA2B1 综合评分: 0.412 · 证据 2 条
- HNRNPM 综合评分: 0.412 · 证据 2 条
- SRSF9 综合评分: 0.398 · 证据 1 条
- HNRNPD 综合评分: 0.362 · 证据 2 条
- HNRNPK 综合评分: 0.362 · 证据 2 条
- RBFOX2 综合评分: 0.362 · 证据 2 条
- HNRNPA1 综合评分: 0.350 · 证据 2 条
- HNRNPH1 综合评分: 0.350 · 证据 2 条
- MBNL1 综合评分: 0.350 · 证据 2 条
- QKI 综合评分: 0.350 · 证据 1 条
- PRPF8 综合评分: 0.324 · 证据 1 条
- Rnps1 综合评分: 0.322 · 证据 1 条
- RBM10 综合评分: 0.312 · 证据 2 条
- RBM15 综合评分: 0.312 · 证据 2 条
- HNRNPU 综合评分: 0.300 · 证据 2 条
🏥 关联疾病
sporadic amyotrophic lateral sclerosis
高关联 (0.812)
essential tremor
高关联 (0.719)
amyotrophic lateral sclerosis
高关联 (0.713)
frontotemporal dementia with motor neuron disease
中关联 (0.661)
juvenile amyotrophic lateral sclerosis
中关联 (0.522)
genetic disorder
中关联 (0.415)
amyotrophic lateral sclerosis, dominant
中关联 (0.413)
liposarcoma
低关联 (0.384)
undifferentiated pleomorphic sarcoma
低关联 (0.371)
synovial sarcoma
低关联 (0.371)