基因注释：GRIA4

官方名称：glutamate ionotropic receptor AMPA type subunit 4

功能摘要：Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The subunit encoded by this gene belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate)-sensitive glutamate receptors, and is subject to RNA editing (AGA->GGA; R->G). Alternative splicing of this gene results in transcript variants encoding different isoforms, which may vary in their signal transduction properties. Some haplotypes of this gene show a positive association with schizophrenia. [provided by RefSeq, Jul 2008].

• FUS 综合评分: 0.300 · 证据 1 条
• RBFOX2 综合评分: 0.300 · 证据 2 条
• SRSF9 综合评分: 0.300 · 证据 1 条
• fus 综合评分: 0.300 · 证据 1 条
• Nova2 综合评分: 0.298 · 证据 1 条
• MBNL2 综合评分: 0.262 · 证据 1 条
• ELAVL3 综合评分: 0.260 · 证据 1 条
• RBM10 综合评分: 0.250 · 证据 2 条
• Mbnl2 综合评分: 0.200 · 证据 1 条
• Ptbp2 综合评分: 0.200 · 证据 1 条
• Srsf3 综合评分: 0.150 · 证据 1 条
• Srsf4 综合评分: 0.150 · 证据 1 条
• Tardbp 综合评分: 0.150 · 证据 1 条
• CSTF2T 综合评分: 0.100 · 证据 2 条
• RBM20 综合评分: 0.100 · 证据 2 条
• Srsf7 综合评分: 0.100 · 证据 1 条

该基因暂无关联疾病记录