🧬 基因注释：HBG1
📝 官方信息
官方名称：hemoglobin subunit gamma 1
功能摘要：The gamma globin genes (HBG1 and HBG2) are normally expressed in the fetal liver, spleen and bone marrow. Two gamma chains together with two alpha chains constitute fetal hemoglobin (HbF) which is normally replaced by adult hemoglobin (HbA) at birth. In some beta-thalassemias and related conditions, gamma chain production continues into adulthood. The two types of gamma chains differ at residue 136 where glycine is found in the G-gamma product (HBG2) and alanine is found in the A-gamma product (HBG1). The former is predominant at birth. The order of the genes in the beta-globin cluster is: 5'-epsilon -- gamma-G -- gamma-A -- delta -- beta--3'. [provided by RefSeq, Jul 2008].
🎯 作为靶基因的剪接因子
- SRSF2 综合评分: 0.444 · 证据 1 条
- HNRNPA1 综合评分: 0.350 · 证据 2 条
- U2af1 综合评分: 0.324 · 证据 1 条
- U2af2 综合评分: 0.274 · 证据 1 条
- PCBP1 综合评分: 0.262 · 证据 2 条
- PRPF8 综合评分: 0.262 · 证据 1 条
- RBM22 综合评分: 0.250 · 证据 2 条
- AQR 综合评分: 0.212 · 证据 1 条
- PABPC4 综合评分: 0.212 · 证据 2 条
- Tardbp 综合评分: 0.212 · 证据 1 条
- LUC7L2 综合评分: 0.162 · 证据 1 条
- CPSF6 综合评分: 0.150 · 证据 2 条
🏥 关联疾病
该基因暂无关联疾病记录