🧬 基因注释：HERC5
📝 官方信息
官方名称：HECT and RLD domain containing E3 ubiquitin protein ligase 5
功能摘要：This gene is a member of the HERC family of ubiquitin ligases and encodes a protein with a HECT domain and five RCC1 repeats. Pro-inflammatory cytokines upregulate expression of this gene in endothelial cells. The protein localizes to the cytoplasm and perinuclear region and functions as an interferon-induced E3 protein ligase that mediates ISGylation of protein targets. The protein also acts as a modulator of the antiviral immune response. The gene lies in a cluster of HERC family genes on chromosome 4. [provided by RefSeq, Aug 2021].
🎯 作为靶基因的剪接因子
🏥 关联疾病
该基因暂无关联疾病记录