🧬 基因注释：HMGB2
📝 官方信息
官方名称：high mobility group box 2
功能摘要：This gene encodes a member of the non-histone chromosomal high mobility group protein family. The proteins of this family are chromatin-associated and ubiquitously distributed in the nucleus of higher eukaryotic cells. In vitro studies have demonstrated that this protein is able to efficiently bend DNA and form DNA circles. These studies suggest a role in facilitating cooperative interactions between cis-acting proteins by promoting DNA flexibility. This protein was also reported to be involved in the final ligation step in DNA end-joining processes of DNA double-strand breaks repair and V(D)J recombination. [provided by RefSeq, Jul 2008].
🎯 作为靶基因的剪接因子
- Tardbp 综合评分: 0.537 · 证据 1 条
- HNRNPC 综合评分: 0.524 · 证据 2 条
- SRSF2 综合评分: 0.496 · 证据 1 条
- RBFOX2 综合评分: 0.486 · 证据 2 条
- HNRNPH1 综合评分: 0.474 · 证据 2 条
- PTBP1 综合评分: 0.460 · 证据 2 条
- HNRNPA1 综合评分: 0.412 · 证据 2 条
- HNRNPF 综合评分: 0.412 · 证据 2 条
- HNRNPM 综合评分: 0.412 · 证据 2 条
- SRSF9 综合评分: 0.398 · 证据 1 条
- EWSR1 综合评分: 0.374 · 证据 2 条
- FUBP1 综合评分: 0.374 · 证据 2 条
- CELF2 综合评分: 0.364 · 证据 2 条
- HNRNPU 综合评分: 0.362 · 证据 2 条
- KHSRP 综合评分: 0.362 · 证据 2 条
- U2af1 综合评分: 0.356 · 证据 1 条
- HNRNPA2B1 综合评分: 0.350 · 证据 2 条
- MBNL1 综合评分: 0.350 · 证据 2 条
- TIA1 综合评分: 0.348 · 证据 1 条
- PRPF8 综合评分: 0.324 · 证据 1 条
🏥 关联疾病
该基因暂无关联疾病记录