基因注释 - HNRNPA1

📝 官方信息

官方名称：heterogeneous nuclear ribonucleoprotein A1

功能摘要：This gene encodes a member of a family of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs), which are RNA-binding proteins that associate with pre-mRNAs in the nucleus and influence pre-mRNA processing, as well as other aspects of mRNA metabolism and transport. The protein encoded by this gene is one of the most abundant core proteins of hnRNP complexes and plays a key role in the regulation of alternative splicing. Mutations in this gene have been observed in individuals with amyotrophic lateral sclerosis 20. Multiple alternatively spliced transcript variants have been found. There are numerous pseudogenes of this gene distributed throughout the genome. [provided by RefSeq, Feb 2016].

🎯 作为靶基因的剪接因子

HNRNPC 综合评分: 0.586 · 证据 2 条
Srsf3 综合评分: 0.460 · 证据 1 条
PTBP1 综合评分: 0.444 · 证据 2 条
SRSF9 综合评分: 0.424 · 证据 1 条
QKI 综合评分: 0.412 · 证据 1 条
U2af1 综合评分: 0.398 · 证据 1 条
TIA1 综合评分: 0.394 · 证据 1 条
FUBP1 综合评分: 0.374 · 证据 2 条
ELAVL3 综合评分: 0.368 · 证据 1 条
HNRNPK 综合评分: 0.362 · 证据 2 条
KHSRP 综合评分: 0.362 · 证据 2 条
RBFOX2 综合评分: 0.362 · 证据 2 条
CELF2 综合评分: 0.356 · 证据 2 条
HNRNPA1 综合评分: 0.350 · 证据 2 条
HNRNPA2B1 综合评分: 0.350 · 证据 2 条
HNRNPF 综合评分: 0.350 · 证据 2 条
HNRNPH1 综合评分: 0.350 · 证据 2 条
HNRNPM 综合评分: 0.350 · 证据 2 条
MBNL1 综合评分: 0.350 · 证据 2 条
PRPF8 综合评分: 0.324 · 证据 1 条

🏥 关联疾病

amyotrophic lateral sclerosis

中关联 (0.641)

chronic progressive multiple sclerosis

中关联 (0.511)

inclusion body myopathy with Paget disease of bone and frontotemporal dementia

中关联 (0.510)

Finnish upper limb-onset distal myopathy

中关联 (0.481)

amyotrophic lateral sclerosis type 20

中关联 (0.432)

inclusion body myopathy with early-onset Paget disease with or without frontotemporal dementia 3

中关联 (0.425)

dengue disease

低关联 (0.370)

severe acute respiratory syndrome

低关联 (0.370)

relapsing-remitting multiple sclerosis

低关联 (0.344)

distal myopathy

低关联 (0.269)

🔍 查看该基因的所有关联疾病

🔗 外部数据库链接

NCBI Gene GenBank Ensembl GeneCards UniProt

🧬 基因注释：HNRNPA1