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🧬 基因注释:HNRNPC

📝 官方信息

官方名称:heterogeneous nuclear ribonucleoprotein C

功能摘要:This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene can act as a tetramer and is involved in the assembly of 40S hnRNP particles. Multiple transcript variants encoding at least two different isoforms have been described for this gene. [provided by RefSeq, Jul 2008].

🎯 作为靶基因的剪接因子
  • HNRNPC 综合评分: 0.586 · 证据 2 条
  • HNRNPA2B1 综合评分: 0.474 · 证据 2 条
  • HNRNPA1 综合评分: 0.448 · 证据 2 条
  • FUS 综合评分: 0.424 · 证据 1 条
  • HNRNPU 综合评分: 0.424 · 证据 2 条
  • PTBP1 综合评分: 0.424 · 证据 2 条
  • Srsf3 综合评分: 0.424 · 证据 1 条
  • fus 综合评分: 0.424 · 证据 1 条
  • HNRNPK 综合评分: 0.398 · 证据 2 条
  • RBFOX2 综合评分: 0.398 · 证据 2 条
  • SRSF2 综合评分: 0.398 · 证据 1 条
  • MBNL2 综合评分: 0.386 · 证据 1 条
  • Nova2 综合评分: 0.374 · 证据 1 条
  • ELAVL3 综合评分: 0.368 · 证据 1 条
  • SRSF9 综合评分: 0.362 · 证据 1 条
  • HNRNPH1 综合评分: 0.350 · 证据 2 条
  • HNRNPM 综合评分: 0.350 · 证据 2 条
  • MBNL1 综合评分: 0.350 · 证据 2 条
  • QKI 综合评分: 0.350 · 证据 1 条
  • EWSR1 综合评分: 0.348 · 证据 2 条
🏥 关联疾病
intellectual developmental disorder, autosomal dominant 74
中关联 (0.483)
dengue disease
低关联 (0.371)
complex neurodevelopmental disorder
低关联 (0.370)
neurodegenerative disease
低关联 (0.358)
genetic disorder
低关联 (0.192)
neoplasm
低关联 (0.105)
cancer
低关联 (0.104)
hepatocellular carcinoma
低关联 (0.101)
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