基因注释 - HNRNPD

📝 官方信息

官方名称：heterogeneous nuclear ribonucleoprotein D

功能摘要：This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are nucleic acid binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. It localizes to both the nucleus and the cytoplasm. This protein is implicated in the regulation of mRNA stability. Alternative splicing of this gene results in four transcript variants. [provided by RefSeq, Jul 2008].

🎯 作为靶基因的剪接因子

HNRNPC 综合评分: 0.510 · 证据 2 条
HNRNPH1 综合评分: 0.474 · 证据 2 条
HNRNPD 综合评分: 0.424 · 证据 2 条
HNRNPA1 综合评分: 0.412 · 证据 2 条
HNRNPA2B1 综合评分: 0.412 · 证据 2 条
Srsf2 综合评分: 0.398 · 证据 1 条
TIA1 综合评分: 0.394 · 证据 1 条
ELAVL3 综合评分: 0.376 · 证据 1 条
HNRNPK 综合评分: 0.362 · 证据 2 条
KHSRP 综合评分: 0.362 · 证据 2 条
Srsf3 综合评分: 0.362 · 证据 1 条
HNRNPF 综合评分: 0.350 · 证据 2 条
HNRNPM 综合评分: 0.350 · 证据 2 条
MBNL1 综合评分: 0.350 · 证据 2 条
EWSR1 综合评分: 0.348 · 证据 2 条
Nova2 综合评分: 0.344 · 证据 1 条
MBNL2 综合评分: 0.324 · 证据 1 条
PCBP2 综合评分: 0.324 · 证据 1 条
PRPF8 综合评分: 0.324 · 证据 1 条
FUBP1 综合评分: 0.312 · 证据 2 条

🏥 关联疾病

dengue disease

中关联 (0.462)

Abnormality of the skeletal system

中关联 (0.421)

mathematical ability

低关联 (0.389)

complex neurodevelopmental disorder

低关联 (0.370)

Intellectual disability

低关联 (0.333)

Neurodevelopmental disorder

低关联 (0.312)

esophageal ulcer

低关联 (0.278)

developmental disorder of mental health

低关联 (0.231)

osteoarthritis, knee

低关联 (0.180)

nephritis

低关联 (0.127)

🔍 查看该基因的所有关联疾病

🔗 外部数据库链接

NCBI Gene GenBank Ensembl GeneCards UniProt

🧬 基因注释：HNRNPD