🧬 基因注释：HSPA5
官方名称：heat shock protein family A (Hsp70) member 5
功能摘要：The protein encoded by this gene is a member of the heat shock protein 70 (HSP70) family. This protein localizes to the lumen of the endoplasmic reticulum (ER) where it operates as a typical HSP70 chaperone involved in the folding and assembly of proteins in the ER and is a master regulator of ER homeostasis. During cellular stress, as during viral infection or tumorogenesis, this protein interacts with the transmembrane stress sensor proteins PERK (protein kinase R-like endoplasmic reticulum kinase), IRE1 (inositol-requiring kinase 1), and ATF6 (activating transcription factor 6) where it acts as a repressor of the unfolded protein response (UPR) and also plays a role in cellular apoptosis and senescence. Elevated expression and atypical translocation of this protein to the cell surface has been reported in viral infections and some types of cancer cells. At the cell surface this protein may facilitate viral attachment and entry to host cells. This gene is a therapeutic target for the treatment of coronavirus diseases and chemoresistant cancers. [provided by RefSeq, Jul 2020].
- FUS 综合评分: 0.522 · 证据 1 条
- fus 综合评分: 0.522 · 证据 1 条
- RBFOX2 综合评分: 0.506 · 证据 2 条
- HNRNPA2B1 综合评分: 0.474 · 证据 2 条
- HNRNPH1 综合评分: 0.474 · 证据 2 条
- Tardbp 综合评分: 0.462 · 证据 1 条
- QKI 综合评分: 0.412 · 证据 1 条
- PTBP1 综合评分: 0.398 · 证据 2 条
- SRSF9 综合评分: 0.398 · 证据 1 条
- Srsf2 综合评分: 0.398 · 证据 1 条
- Srsf3 综合评分: 0.398 · 证据 1 条
- HNRNPU 综合评分: 0.362 · 证据 2 条
- HNRNPA1 综合评分: 0.350 · 证据 2 条
- HNRNPC 综合评分: 0.350 · 证据 2 条
- HNRNPM 综合评分: 0.350 · 证据 2 条
- MBNL1 综合评分: 0.350 · 证据 2 条
- Rnps1 综合评分: 0.342 · 证据 1 条
- PCBP2 综合评分: 0.324 · 证据 1 条
- EWSR1 综合评分: 0.312 · 证据 2 条
- RBM10 综合评分: 0.312 · 证据 2 条
该基因暂无关联疾病记录