🧬 基因注释：IL10RA
📝 官方信息
官方名称：interleukin 10 receptor subunit alpha
功能摘要：The protein encoded by this gene is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene. [provided by RefSeq, Jan 2009].
🎯 作为靶基因的剪接因子
- HNRNPL 置信度: 2.0
🏥 关联疾病
该基因暂无关联疾病记录