🧬 基因注释：ILF2

官方名称：interleukin enhancer binding factor 2

功能摘要：The protein encoded by this gene is a transcription factor required for T-cell expression of the interleukin 2 gene. It also binds RNA and is an essential component for encapsidation and protein priming of hepatitis B viral polymerase. The encoded 45 kDa protein (NF45, ILF2) forms a complex with the 90 kDa interleukin enhancer-binding factor 3 (NF90, ILF3), and this complex has been shown to affect the redistribution of nuclear mRNA to the cytoplasm, to repair DNA breaks by nonhomologous end joining, and to negatively regulate the microRNA processing pathway. Knockdown of NF45 or NF90 protein retards cell growth, possibly by inhibition of mRNA stabilization. Alternative splicing results in multiple transcript variants. Related pseudogenes have been found on chromosomes 3 and 14. [provided by RefSeq, Dec 2014].

• HNRNPC 综合评分: 0.510 · 证据 2 条
• FUS 综合评分: 0.486 · 证据 1 条
• fus 综合评分: 0.486 · 证据 1 条
• Tardbp 综合评分: 0.444 · 证据 1 条
• PTBP1 综合评分: 0.424 · 证据 2 条
• HNRNPA2B1 综合评分: 0.412 · 证据 2 条
• HNRNPM 综合评分: 0.412 · 证据 2 条
• U2af1 综合评分: 0.379 · 证据 1 条
• RBFOX2 综合评分: 0.362 · 证据 2 条
• SRSF2 综合评分: 0.362 · 证据 1 条
• SRSF9 综合评分: 0.362 · 证据 1 条
• Srsf2 综合评分: 0.362 · 证据 1 条
• Srsf3 综合评分: 0.362 · 证据 1 条
• PCBP2 综合评分: 0.360 · 证据 1 条
• HNRNPA1 综合评分: 0.350 · 证据 2 条
• U2af2 综合评分: 0.342 · 证据 1 条
• PRPF8 综合评分: 0.324 · 证据 1 条
• Srsf1 综合评分: 0.324 · 证据 1 条
• EWSR1 综合评分: 0.312 · 证据 2 条
• RBM10 综合评分: 0.312 · 证据 2 条

该基因暂无关联疾病记录