🧬 基因注释：LSM1
📝 官方信息
官方名称：LSM1 homolog, mRNA degradation associated
功能摘要：This gene encodes a member of the LSm family of RNA-binding proteins. LSm proteins form stable heteromers that bind specifically to the 3'-terminal oligo(U) tract of U6 snRNA and may play a role in pre-mRNA splicing by mediating U4/U6 snRNP formation. Increased expression of this gene may play a role in cellular transformation and the progression of several malignancies including lung cancer, mesothelioma and breast cancer. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, Nov 2011].
🎯 作为靶基因的剪接因子
- HNRNPC 综合评分: 0.510 · 证据 2 条
- FUS 综合评分: 0.424 · 证据 1 条
- fus 综合评分: 0.424 · 证据 1 条
- HNRNPA2B1 综合评分: 0.412 · 证据 2 条
- EWSR1 综合评分: 0.312 · 证据 2 条
- RBM10 综合评分: 0.312 · 证据 2 条
- HNRNPK 综合评分: 0.300 · 证据 2 条
- HNRNPL 综合评分: 0.300 · 证据 2 条
- HNRNPU 综合评分: 0.300 · 证据 2 条
- PTBP1 综合评分: 0.300 · 证据 2 条
- SRSF3 综合评分: 0.300 · 证据 1 条
- SRSF9 综合评分: 0.300 · 证据 1 条
- Srsf3 综合评分: 0.300 · 证据 1 条
- Tardbp 综合评分: 0.274 · 证据 1 条
- PCBP2 综合评分: 0.262 · 证据 1 条
- Rbmx 综合评分: 0.260 · 证据 1 条
- RBM15 综合评分: 0.250 · 证据 2 条
- GRSF1 综合评分: 0.248 · 证据 2 条
- UPF1 综合评分: 0.224 · 证据 1 条
- MATR3 综合评分: 0.200 · 证据 1 条
🏥 关联疾病
Global developmental delay
低关联 (0.262)
risk-taking behaviour
低关联 (0.153)
schizophrenia
低关联 (0.145)
gout
低关联 (0.143)
Neurodevelopmental delay
低关联 (0.119)
Mitral stenosis
低关联 (0.118)
Abnormal facial shape
低关联 (0.118)
Bicuspid aortic valve
低关联 (0.118)
Perimembranous ventricular septal defect
低关联 (0.118)
Penile hypospadias
低关联 (0.118)