🧬 基因注释：MAPKAPK3

官方名称：MAPK activated protein kinase 3

功能摘要：This gene encodes a member of the Ser/Thr protein kinase family. This kinase functions as a mitogen-activated protein kinase (MAP kinase)- activated protein kinase. MAP kinases are also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This kinase was shown to be activated by growth inducers and stress stimulation of cells. In vitro studies demonstrated that ERK, p38 MAP kinase and Jun N-terminal kinase were all able to phosphorylate and activate this kinase, which suggested the role of this kinase as an integrative element of signaling in both mitogen and stress responses. This kinase was reported to interact with, phosphorylate and repress the activity of E47, which is a basic helix-loop-helix transcription factor known to be involved in the regulation of tissue-specific gene expression and cell differentiation. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2011].

• HNRNPK 综合评分: 0.362 · 证据 2 条
• HNRNPL 综合评分: 0.362 · 证据 2 条
• HNRNPA2B1 综合评分: 0.350 · 证据 2 条
• HNRNPM 综合评分: 0.350 · 证据 2 条
• MBNL1 综合评分: 0.350 · 证据 2 条
• RBM15 综合评分: 0.312 · 证据 2 条
• PTBP1 综合评分: 0.300 · 证据 2 条
• RBFOX2 综合评分: 0.300 · 证据 2 条
• Tardbp 综合评分: 0.294 · 证据 1 条
• PRPF8 综合评分: 0.262 · 证据 1 条
• U2af1 综合评分: 0.248 · 证据 1 条
• PCBP2 综合评分: 0.200 · 证据 1 条
• U2af2 综合评分: 0.198 · 证据 1 条
• YBX1 综合评分: 0.198 · 证据 1 条
• NXF1 综合评分: 0.162 · 证据 1 条
• Rnps1 综合评分: 0.162 · 证据 1 条
• CPSF7 综合评分: 0.150 · 证据 2 条
• CSTF2 综合评分: 0.150 · 证据 2 条
• GRSF1 综合评分: 0.150 · 证据 2 条
• Srsf1 综合评分: 0.150 · 证据 1 条

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