🧬 基因注释：MCM3

官方名称：minichromosome maintenance complex component 3

功能摘要：The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein is a subunit of the protein complex that consists of MCM2-7. It has been shown to interact directly with MCM5/CDC46. This protein also interacts with and is acetylated by MCM3AP, a chromatin-associated acetyltransferase. The acetylation of this protein inhibits the initiation of DNA replication and cell cycle progression. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2018].

• HNRNPC 综合评分: 0.536 · 证据 2 条
• RBFOX2 综合评分: 0.496 · 证据 2 条
• FUS 综合评分: 0.460 · 证据 1 条
• fus 综合评分: 0.460 · 证据 1 条
• HNRNPA2B1 综合评分: 0.412 · 证据 2 条
• EWSR1 综合评分: 0.374 · 证据 2 条
• PTBP1 综合评分: 0.362 · 证据 2 条
• U2af1 综合评分: 0.356 · 证据 1 条
• HNRNPM 综合评分: 0.350 · 证据 2 条
• MBNL1 综合评分: 0.350 · 证据 2 条
• U2af2 综合评分: 0.342 · 证据 1 条
• PRPF8 综合评分: 0.324 · 证据 1 条
• Rnps1 综合评分: 0.322 · 证据 1 条
• RBM10 综合评分: 0.312 · 证据 2 条
• RBM22 综合评分: 0.312 · 证据 2 条
• RBM39 综合评分: 0.312 · 证据 2 条
• TIA1 综合评分: 0.312 · 证据 1 条
• CELF2 综合评分: 0.310 · 证据 2 条
• Tardbp 综合评分: 0.310 · 证据 1 条
• HNRNPK 综合评分: 0.300 · 证据 2 条

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