🧬 基因注释：MCM7

官方名称：minichromosome maintenance complex component 7

功能摘要：The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. Cyclin D1-dependent kinase, CDK4, is found to associate with this protein, and may regulate the binding of this protein with the tumorsuppressor protein RB1/RB. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008].

• Tardbp 综合评分: 0.490 · 证据 1 条
• FUS 综合评分: 0.474 · 证据 1 条
• HNRNPC 综合评分: 0.474 · 证据 2 条
• QKI 综合评分: 0.474 · 证据 1 条
• fus 综合评分: 0.474 · 证据 1 条
• RBFOX2 综合评分: 0.424 · 证据 2 条
• HNRNPA2B1 综合评分: 0.412 · 证据 2 条
• HNRNPH1 综合评分: 0.412 · 证据 2 条
• HNRNPM 综合评分: 0.412 · 证据 2 条
• Srsf3 综合评分: 0.398 · 证据 1 条
• HNRNPK 综合评分: 0.362 · 证据 2 条
• PTBP1 综合评分: 0.362 · 证据 2 条
• MBNL1 综合评分: 0.350 · 证据 2 条
• Rnps1 综合评分: 0.329 · 证据 1 条
• PCBP2 综合评分: 0.324 · 证据 1 条
• U2af2 综合评分: 0.314 · 证据 1 条
• RBM10 综合评分: 0.312 · 证据 2 条
• RBM15 综合评分: 0.312 · 证据 2 条
• RBM22 综合评分: 0.312 · 证据 2 条
• HNRNPD 综合评分: 0.300 · 证据 2 条

该基因暂无关联疾病记录