🧬 基因注释：MLKL
官方名称：mixed lineage kinase domain like pseudokinase
功能摘要：This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2015].
- ACIN1 置信度: 2.0
- CSTF2 置信度: 2.0
- CSTF2T 置信度: 2.0
- EIF4A3 置信度: 2.0
- HNRNPA2B1 置信度: 2.0
- HNRNPC 置信度: 2.0
- HNRNPH1 置信度: 2.0
- HNRNPK 置信度: 2.0
- PTBP1 置信度: 2.0
- RBM10 置信度: 2.0
- RBM39 置信度: 2.0
- PRPF8 置信度: 1.0
- Rbpms 置信度: 1.0
- Rnps1 置信度: 1.0
- SRSF2 置信度: 1.0
- Srsf1 置信度: 1.0
- Srsf2 置信度: 1.0
- Tardbp 置信度: 1.0
- Tra2b 置信度: 1.0
- U2af1 置信度: 1.0
该基因暂无关联疾病记录