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🧬 基因注释:MMP14

📝 官方信息

官方名称:matrix metallopeptidase 14

功能摘要:Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 protein, and this activity may be involved in tumor invasion. [provided by RefSeq, Jul 2008].

🎯 作为靶基因的剪接因子
  • HNRNPA2B1 综合评分: 0.412 · 证据 2 条
  • HNRNPH1 综合评分: 0.350 · 证据 2 条
  • MBNL1 综合评分: 0.350 · 证据 2 条
  • QKI 综合评分: 0.350 · 证据 1 条
  • RBM39 综合评分: 0.312 · 证据 2 条
  • TIA1 综合评分: 0.312 · 证据 1 条
  • RBFOX2 综合评分: 0.300 · 证据 2 条
  • SRSF3 综合评分: 0.300 · 证据 1 条
  • RBM10 综合评分: 0.250 · 证据 2 条
  • U2af2 综合评分: 0.244 · 证据 1 条
  • YBX1 综合评分: 0.224 · 证据 1 条
  • PRPF4 综合评分: 0.212 · 证据 1 条
  • Mbnl2 综合评分: 0.200 · 证据 1 条
  • PCBP2 综合评分: 0.200 · 证据 1 条
  • PRPF8 综合评分: 0.200 · 证据 1 条
  • CSTF2T 综合评分: 0.162 · 证据 2 条
  • Rbmx 综合评分: 0.162 · 证据 1 条
  • Rbpms 综合评分: 0.162 · 证据 1 条
  • Tra2b 综合评分: 0.162 · 证据 1 条
  • UPF1 综合评分: 0.162 · 证据 1 条
🏥 关联疾病

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