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🧬 基因注释:MRPL2

📝 官方信息

官方名称:mitochondrial ribosomal protein L2

功能摘要:Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the EcoL2 ribosomal protein family. A pseudogene corresponding to this gene is found on chromosome 12q. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014].

🎯 作为靶基因的剪接因子
  • HNRNPA2B1 综合评分: 0.350 · 证据 2 条
  • MBNL1 综合评分: 0.350 · 证据 2 条
  • PCBP2 综合评分: 0.324 · 证据 1 条
  • FUS 综合评分: 0.300 · 证据 1 条
  • PTBP1 综合评分: 0.300 · 证据 2 条
  • RBFOX2 综合评分: 0.300 · 证据 2 条
  • fus 综合评分: 0.300 · 证据 1 条
  • U2af2 综合评分: 0.286 · 证据 1 条
  • CSTF2 综合评分: 0.274 · 证据 2 条
  • Tardbp 综合评分: 0.274 · 证据 1 条
  • PRPF8 综合评分: 0.262 · 证据 1 条
  • SF3A3 综合评分: 0.262 · 证据 1 条
  • EWSR1 综合评分: 0.250 · 证据 2 条
  • RBM10 综合评分: 0.250 · 证据 2 条
  • RBM15 综合评分: 0.250 · 证据 2 条
  • Srsf1 综合评分: 0.248 · 证据 1 条
  • Srsf2 综合评分: 0.212 · 证据 1 条
  • U2af1 综合评分: 0.212 · 证据 1 条
  • CPSF4 综合评分: 0.150 · 证据 2 条
  • CPSF6 综合评分: 0.150 · 证据 2 条
🏥 关联疾病

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