🧬 基因注释：MANF
📝 官方信息
官方名称：mesencephalic astrocyte derived neurotrophic factor
功能摘要：The protein encoded by this gene is localized in the endoplasmic reticulum (ER) and golgi, and is also secreted. Reducing expression of this gene increases susceptibility to ER stress-induced death and results in cell proliferation. Activity of this protein is important in promoting the survival of dopaminergic neurons. The presence of polymorphisms in the N-terminal arginine-rich region, including a specific mutation that changes an ATG start codon to AGG, have been reported in a variety of solid tumors; however, these polymorphisms were later shown to exist in normal tissues and are thus no longer thought to be tumor-related. [provided by RefSeq, Apr 2014].
🎯 作为靶基因的剪接因子
- HNRNPC 综合评分: 0.510 · 证据 2 条
- HNRNPA2B1 综合评分: 0.412 · 证据 2 条
- RBFOX2 综合评分: 0.398 · 证据 2 条
- Srsf2 综合评分: 0.398 · 证据 1 条
- HNRNPH1 综合评分: 0.350 · 证据 2 条
- MBNL1 综合评分: 0.350 · 证据 2 条
- RBM10 综合评分: 0.312 · 证据 2 条
- TIA1 综合评分: 0.312 · 证据 1 条
- FUS 综合评分: 0.300 · 证据 1 条
- PTBP1 综合评分: 0.300 · 证据 2 条
- SRSF2 综合评分: 0.300 · 证据 1 条
- SRSF9 综合评分: 0.300 · 证据 1 条
- fus 综合评分: 0.300 · 证据 1 条
- Ptbp2 综合评分: 0.298 · 证据 1 条
- Srsf1 综合评分: 0.294 · 证据 1 条
- Tardbp 综合评分: 0.274 · 证据 1 条
- PRPF8 综合评分: 0.262 · 证据 1 条
- RBM15 综合评分: 0.250 · 证据 2 条
- Rnps1 综合评分: 0.224 · 证据 1 条
- AQR 综合评分: 0.212 · 证据 1 条
🏥 关联疾病
该基因暂无关联疾病记录