🧬 基因注释：NPM1
📝 官方信息
官方名称：nucleophosmin 1
功能摘要：The protein encoded by this gene is involved in several cellular processes, including centrosome duplication, protein chaperoning, and cell proliferation. The encoded phosphoprotein shuttles between the nucleolus, nucleus, and cytoplasm, chaperoning ribosomal proteins and core histones from the nucleus to the cytoplasm. This protein is also known to sequester the tumor suppressor ARF in the nucleolus, protecting it from degradation until it is needed. Mutations in this gene are associated with acute myeloid leukemia. Dozens of pseudogenes of this gene have been identified. [provided by RefSeq, Aug 2017].
🎯 作为靶基因的剪接因子
- HNRNPC 综合评分: 0.524 · 证据 2 条
- HNRNPH1 综合评分: 0.494 · 证据 2 条
- HNRNPM 综合评分: 0.474 · 证据 2 条
- Srsf3 综合评分: 0.460 · 证据 1 条
- HNRNPL 综合评分: 0.444 · 证据 2 条
- RBFOX2 综合评分: 0.444 · 证据 2 条
- SRSF9 综合评分: 0.444 · 证据 1 条
- Tardbp 综合评分: 0.441 · 证据 1 条
- PTBP1 综合评分: 0.424 · 证据 2 条
- HNRNPA2B1 综合评分: 0.412 · 证据 2 条
- QKI 综合评分: 0.412 · 证据 1 条
- Srsf2 综合评分: 0.398 · 证据 1 条
- U2af1 综合评分: 0.386 · 证据 1 条
- FUS 综合评分: 0.362 · 证据 1 条
- fus 综合评分: 0.362 · 证据 1 条
- HNRNPA1 综合评分: 0.350 · 证据 2 条
- MBNL1 综合评分: 0.350 · 证据 2 条
- Rnps1 综合评分: 0.329 · 证据 1 条
- PRPF8 综合评分: 0.324 · 证据 1 条
- EWSR1 综合评分: 0.312 · 证据 2 条
🏥 关联疾病
该基因暂无关联疾病记录