🧬 基因注释：P4HB

官方名称：prolyl 4-hydroxylase subunit beta

功能摘要：This gene encodes the beta subunit of prolyl 4-hydroxylase, a highly abundant multifunctional enzyme that belongs to the protein disulfide isomerase family. When present as a tetramer consisting of two alpha and two beta subunits, this enzyme is involved in hydroxylation of prolyl residues in preprocollagen. This enzyme is also a disulfide isomerase containing two thioredoxin domains that catalyze the formation, breakage and rearrangement of disulfide bonds. Other known functions include its ability to act as a chaperone that inhibits aggregation of misfolded proteins in a concentration-dependent manner, its ability to bind thyroid hormone, its role in both the influx and efflux of S-nitrosothiol-bound nitric oxide, and its function as a subunit of the microsomal triglyceride transfer protein complex. [provided by RefSeq, Jul 2008].

• HNRNPC 综合评分: 0.592 · 证据 2 条
• RBFOX2 综合评分: 0.486 · 证据 2 条
• PTBP1 综合评分: 0.474 · 证据 2 条
• Tardbp 综合评分: 0.465 · 证据 1 条
• HNRNPA2B1 综合评分: 0.412 · 证据 2 条
• HNRNPM 综合评分: 0.412 · 证据 2 条
• FUS 综合评分: 0.398 · 证据 1 条
• HNRNPL 综合评分: 0.398 · 证据 2 条
• Srsf3 综合评分: 0.398 · 证据 1 条
• fus 综合评分: 0.398 · 证据 1 条
• TIA1 综合评分: 0.374 · 证据 1 条
• Srsf2 综合评分: 0.362 · 证据 1 条
• Nova2 综合评分: 0.360 · 证据 1 条
• Rnps1 综合评分: 0.353 · 证据 1 条
• HNRNPA1 综合评分: 0.350 · 证据 2 条
• HNRNPH1 综合评分: 0.350 · 证据 2 条
• MBNL1 综合评分: 0.350 · 证据 2 条
• Mbnl2 综合评分: 0.324 · 证据 1 条
• UPF1 综合评分: 0.314 · 证据 1 条
• RBM10 综合评分: 0.312 · 证据 2 条

该基因暂无关联疾病记录