🧬 基因注释：PGC

官方名称：progastricsin

功能摘要：This gene encodes an aspartic proteinase that belongs to the peptidase family A1. The encoded protein is a digestive enzyme that is produced in the stomach and constitutes a major component of the gastric mucosa. This protein is also secreted into the serum. This protein is synthesized as an inactive zymogen that includes a highly basic prosegment. This enzyme is converted into its active mature form at low pH by sequential cleavage of the prosegment that is carried out by the enzyme itself. Polymorphisms in this gene are associated with susceptibility to gastric cancers. Serum levels of this enzyme are used as a biomarker for certain gastric diseases including Helicobacter pylori related gastritis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 1. [provided by RefSeq, Oct 2009].

• HNRNPK 综合评分: 0.362 · 证据 2 条
• RBFOX2 综合评分: 0.362 · 证据 2 条
• HNRNPC 综合评分: 0.350 · 证据 2 条
• TIA1 综合评分: 0.312 · 证据 1 条
• PCBP2 综合评分: 0.262 · 证据 1 条
• PRPF8 综合评分: 0.262 · 证据 1 条
• U2af1 综合评分: 0.212 · 证据 1 条
• CSTF2T 综合评分: 0.100 · 证据 2 条
• SMNDC1 综合评分: 0.100 · 证据 1 条
• Tra2a 综合评分: 0.100 · 证据 1 条
• U2af2 综合评分: 0.100 · 证据 1 条

该基因暂无关联疾病记录