🧬 基因注释：PPP1R8
📝 官方信息
官方名称：protein phosphatase 1 regulatory subunit 8
功能摘要：This gene, through alternative splicing, encodes three different isoforms. Two of the protein isoforms encoded by this gene are specific inhibitors of type 1 serine/threonine protein phosphatases and can bind but not cleave RNA. The third protein isoform lacks the phosphatase inhibitory function but is a single-strand endoribonuclease comparable to RNase E of E. coli. This isoform requires magnesium for its function and cleaves specific sites in A+U-rich regions of RNA. [provided by RefSeq, Jul 2008].
🎯 作为靶基因的剪接因子
- HNRNPC 综合评分: 0.494 · 证据 2 条
- PTBP1 综合评分: 0.460 · 证据 2 条
- RBFOX2 综合评分: 0.460 · 证据 2 条
- HNRNPH1 综合评分: 0.448 · 证据 2 条
- HNRNPL 综合评分: 0.398 · 证据 2 条
- Srsf3 综合评分: 0.362 · 证据 1 条
- HNRNPA1 综合评分: 0.350 · 证据 2 条
- HNRNPA2B1 综合评分: 0.350 · 证据 2 条
- HNRNPM 综合评分: 0.350 · 证据 2 条
- MBNL1 综合评分: 0.350 · 证据 2 条
- QKI 综合评分: 0.350 · 证据 1 条
- Rnps1 综合评分: 0.342 · 证据 1 条
- RBM10 综合评分: 0.312 · 证据 2 条
- FUS 综合评分: 0.300 · 证据 1 条
- HNRNPU 综合评分: 0.300 · 证据 2 条
- KHSRP 综合评分: 0.300 · 证据 2 条
- SRSF3 综合评分: 0.300 · 证据 1 条
- fus 综合评分: 0.300 · 证据 1 条
- ACIN1 综合评分: 0.294 · 证据 2 条
- GRSF1 综合评分: 0.274 · 证据 2 条
🏥 关联疾病
neurodegenerative disease
中关联 (0.550)
neuroinflammatory disorder
低关联 (0.226)