🧬 基因注释：PTPA
官方名称：protein phosphatase 2 phosphatase activator
功能摘要：Protein phosphatase 2A (PP2A) is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. The core PP2A holoenzyme is a heterotrimer of a structural A subunit, a catalytic C subunit, and one of several regulatory B subunits, which are grouped into distinct families (B/PR55, B'/PR61, B''/PR72) that confer different substrate specificities and localizations. This gene, PTPA, does not encode one of these conventional B-type regulatory subunits. Rather, this PTPA gene encodes a peptidyl-prolyl cis-trans isomerase that acts as a Mg-ion and ATP-dependent activation chaperone, transiently engaging the PP2A A-C core dimer to restore its catalytic activity, including a distinct phosphotyrosyl phosphatase activity. Unlike classic B-family subunits, which dock stably onto the holoenzyme to alter its specificity, PTPA dissociates after activation rather than remaining a permanent structural component. PTPA was historically classified within the B' family, but this reflects an older nomenclature scheme rather than its actual mechanism, which is now understood to be that of a dedicated activator rather than a structural regulatory subunit. Note that PP2A was used as a symbol for this gene in early publications when its distinct chaperone function was not yet clearly distinguished from the holoenzyme it regulates. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2026].
- HNRNPA2B1 综合评分: 0.412 · 证据 2 条
- HNRNPC 综合评分: 0.412 · 证据 2 条
- FUS 综合评分: 0.362 · 证据 1 条
- HNRNPK 综合评分: 0.362 · 证据 2 条
- RBFOX2 综合评分: 0.362 · 证据 2 条
- Srsf3 综合评分: 0.362 · 证据 1 条
- fus 综合评分: 0.362 · 证据 1 条
- HNRNPH1 综合评分: 0.350 · 证据 2 条
- HNRNPM 综合评分: 0.350 · 证据 2 条
- MBNL1 综合评分: 0.350 · 证据 2 条
- Tardbp 综合评分: 0.310 · 证据 1 条
- HNRNPU 综合评分: 0.300 · 证据 2 条
- PTBP1 综合评分: 0.300 · 证据 2 条
- SRSF3 综合评分: 0.300 · 证据 1 条
- PRPF8 综合评分: 0.298 · 证据 1 条
- Mbnl2 综合评分: 0.262 · 证据 1 条
- RBM10 综合评分: 0.250 · 证据 2 条
- RBM15 综合评分: 0.250 · 证据 2 条
- Rbmx 综合评分: 0.224 · 证据 1 条
- CPSF6 综合评分: 0.212 · 证据 2 条
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