SpliceAtlasDB
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🧬 基因注释:PA2G4

📝 官方信息

官方名称:proliferation-associated 2G4

功能摘要:This gene encodes an RNA-binding protein that is involved in growth regulation. This protein is present in pre-ribosomal ribonucleoprotein complexes and may be involved in ribosome assembly and the regulation of intermediate and late steps of rRNA processing. This protein can interact with the cytoplasmic domain of the ErbB3 receptor and may contribute to transducing growth regulatory signals. This protein is also a transcriptional co-repressor of androgen receptor-regulated genes and other cell cycle regulatory genes through its interactions with histone deacetylases. This protein has been implicated in growth inhibition and the induction of differentiation of human cancer cells. Six pseudogenes, located on chromosomes 3, 6, 9, 18, 20 and X, have been identified. [provided by RefSeq, Jul 2008].

🎯 作为靶基因的剪接因子
  • HNRNPK 综合评分: 0.460 · 证据 2 条
  • HNRNPC 综合评分: 0.448 · 证据 2 条
  • RBFOX2 综合评分: 0.444 · 证据 2 条
  • Srsf3 综合评分: 0.444 · 证据 1 条
  • HNRNPA2B1 综合评分: 0.412 · 证据 2 条
  • HNRNPM 综合评分: 0.412 · 证据 2 条
  • Tardbp 综合评分: 0.379 · 证据 1 条
  • FUS 综合评分: 0.362 · 证据 1 条
  • PTBP1 综合评分: 0.362 · 证据 2 条
  • SRSF2 综合评分: 0.362 · 证据 1 条
  • fus 综合评分: 0.362 · 证据 1 条
  • HNRNPA1 综合评分: 0.350 · 证据 2 条
  • Rnps1 综合评分: 0.336 · 证据 1 条
  • PRPF8 综合评分: 0.324 · 证据 1 条
  • RBM10 综合评分: 0.312 · 证据 2 条
  • RBM39 综合评分: 0.312 · 证据 2 条
  • TIA1 综合评分: 0.312 · 证据 1 条
  • HNRNPL 综合评分: 0.300 · 证据 2 条
  • HNRNPU 综合评分: 0.300 · 证据 2 条
  • SRSF3 综合评分: 0.300 · 证据 1 条
🏥 关联疾病

该基因暂无关联疾病记录

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