🧬 基因注释：PABPC1
📝 官方信息
官方名称：poly(A) binding protein cytoplasmic 1
功能摘要：This gene encodes a poly(A) binding protein. The protein shuttles between the nucleus and cytoplasm and binds to the 3' poly(A) tail of eukaryotic messenger RNAs via RNA-recognition motifs. The binding of this protein to poly(A) promotes ribosome recruitment and translation initiation; it is also required for poly(A) shortening which is the first step in mRNA decay. The gene is part of a small gene family including three protein-coding genes and several pseudogenes.[provided by RefSeq, Aug 2010].
🎯 作为靶基因的剪接因子
- HNRNPC 综合评分: 0.494 · 证据 2 条
- Srsf3 综合评分: 0.460 · 证据 1 条
- Srsf2 综合评分: 0.362 · 证据 1 条
- HNRNPA1 综合评分: 0.350 · 证据 2 条
- HNRNPA2B1 综合评分: 0.350 · 证据 2 条
- HNRNPF 综合评分: 0.350 · 证据 2 条
- HNRNPH1 综合评分: 0.350 · 证据 2 条
- HNRNPM 综合评分: 0.350 · 证据 2 条
- MBNL1 综合评分: 0.350 · 证据 2 条
- QKI 综合评分: 0.350 · 证据 1 条
- Rnps1 综合评分: 0.336 · 证据 1 条
- PCBP2 综合评分: 0.324 · 证据 1 条
- RBM10 综合评分: 0.312 · 证据 2 条
- TIA1 综合评分: 0.312 · 证据 1 条
- ACIN1 综合评分: 0.310 · 证据 2 条
- FUS 综合评分: 0.300 · 证据 1 条
- HNRNPD 综合评分: 0.300 · 证据 2 条
- HNRNPK 综合评分: 0.300 · 证据 2 条
- HNRNPL 综合评分: 0.300 · 证据 2 条
- HNRNPU 综合评分: 0.300 · 证据 2 条
🏥 关联疾病
Intellectual disability
中关联 (0.529)
Global developmental delay
中关联 (0.466)
Atypical behavior
中关联 (0.462)
Expressive language delay
中关联 (0.462)
Seizure
中关联 (0.462)
neurodegenerative disease
中关联 (0.458)
hepatocellular carcinoma
中关联 (0.424)
multiple myeloma
中关联 (0.416)
dengue disease
低关联 (0.376)
Pulmonary artery atresia
低关联 (0.333)