🧬 基因注释：PCBP1
官方名称：poly(rC) binding protein 1
功能摘要：This intronless gene is thought to have been generated by retrotransposition of a fully processed PCBP-2 mRNA. This gene and PCBP-2 have paralogues (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. The protein encoded by this gene appears to be multifunctional. It along with PCBP-2 and hnRNPK corresponds to the major cellular poly(rC)-binding protein. It contains three K-homologous (KH) domains which may be involved in RNA binding. This encoded protein together with PCBP-2 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. [provided by RefSeq, Jul 2008].
- HNRNPC 综合评分: 0.448 · 证据 2 条
- KHSRP 综合评分: 0.444 · 证据 2 条
- FUS 综合评分: 0.424 · 证据 1 条
- Srsf3 综合评分: 0.424 · 证据 1 条
- fus 综合评分: 0.424 · 证据 1 条
- Tardbp 综合评分: 0.413 · 证据 1 条
- EWSR1 综合评分: 0.374 · 证据 2 条
- PTBP1 综合评分: 0.362 · 证据 2 条
- RBFOX2 综合评分: 0.362 · 证据 2 条
- Srsf2 综合评分: 0.362 · 证据 1 条
- HNRNPA2B1 综合评分: 0.350 · 证据 2 条
- MBNL1 综合评分: 0.350 · 证据 2 条
- Nova2 综合评分: 0.324 · 证据 1 条
- PCBP2 综合评分: 0.324 · 证据 1 条
- Rnps1 综合评分: 0.322 · 证据 1 条
- FUBP1 综合评分: 0.312 · 证据 2 条
- RBM10 综合评分: 0.312 · 证据 2 条
- TIA1 综合评分: 0.312 · 证据 1 条
- U2af1 综合评分: 0.310 · 证据 1 条
- HNRNPL 综合评分: 0.300 · 证据 2 条