🧬 基因注释:PHF5A
📝 官方信息
官方名称:PHD finger protein 5A
功能摘要:This gene encodes a subunit of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence-independent manner and may anchor the U2 snRNP to the pre-mRNA. The protein encoded by this gene contains a PHD-finger-like domain that is flanked by highly basic N- and C-termini. This protein belongs to the PHD-finger superfamily and may act as a chromatin-associated protein. This gene has several pseudogenes on different chromosomes. [provided by RefSeq, Jul 2008].
🎯 作为靶基因的剪接因子
- HNRNPC 综合评分: 0.510 · 证据 2 条
- HNRNPA2B1 综合评分: 0.412 · 证据 2 条
- Tardbp 综合评分: 0.372 · 证据 1 条
- PCBP2 综合评分: 0.324 · 证据 1 条
- EWSR1 综合评分: 0.312 · 证据 2 条
- RBM15 综合评分: 0.312 · 证据 2 条
- TIA1 综合评分: 0.312 · 证据 1 条
- UPF1 综合评分: 0.306 · 证据 1 条
- FUS 综合评分: 0.300 · 证据 1 条
- SRSF3 综合评分: 0.300 · 证据 1 条
- SRSF9 综合评分: 0.300 · 证据 1 条
- Srsf3 综合评分: 0.300 · 证据 1 条
- fus 综合评分: 0.300 · 证据 1 条
- GRSF1 综合评分: 0.274 · 证据 2 条
- PRPF8 综合评分: 0.262 · 证据 1 条
- RBM10 综合评分: 0.250 · 证据 2 条
- Srsf1 综合评分: 0.248 · 证据 1 条
- Rbmx 综合评分: 0.244 · 证据 1 条
- YBX1 综合评分: 0.244 · 证据 1 条
- U2af1 综合评分: 0.212 · 证据 1 条
🏥 关联疾病
dengue disease
低关联 (0.370)
neurodegenerative disease
低关联 (0.349)
refractive error
低关联 (0.230)
complex neurodevelopmental disorder
低关联 (0.185)
asthma
低关联 (0.173)
childhood onset asthma
低关联 (0.154)
genetic disorder
低关联 (0.118)
neoplasm
低关联 (0.102)