🧬 基因注释：PKM
📝 官方信息
官方名称：pyruvate kinase M1/2
功能摘要：This gene encodes a protein involved in glycolysis. The encoded protein is a pyruvate kinase that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate to ADP, generating ATP and pyruvate. This protein has been shown to interact with thyroid hormone and may mediate cellular metabolic effects induced by thyroid hormones. This protein has been found to bind Opa protein, a bacterial outer membrane protein involved in gonococcal adherence to and invasion of human cells, suggesting a role of this protein in bacterial pathogenesis. Several alternatively spliced transcript variants encoding a few distinct isoforms have been reported. [provided by RefSeq, May 2011].
🎯 作为靶基因的剪接因子
- HNRNPA1 综合评分: 0.636 · 证据 2 条
- PTBP1 综合评分: 0.586 · 证据 2 条
- FUS 综合评分: 0.514 · 证据 1 条
- fus 综合评分: 0.514 · 证据 1 条
- Srsf3 综合评分: 0.424 · 证据 1 条
- Tardbp 综合评分: 0.418 · 证据 1 条
- HNRNPA2B1 综合评分: 0.407 · 证据 2 条
- HNRNPC 综合评分: 0.407 · 证据 2 条
- Srsf2 综合评分: 0.398 · 证据 2 条
- CELF1 综合评分: 0.364 · 证据 1 条
- Celf1 综合评分: 0.364 · 证据 1 条
- celf1 综合评分: 0.364 · 证据 1 条
- U2af1 综合评分: 0.364 · 证据 1 条
- PCBP2 综合评分: 0.360 · 证据 1 条
- HNRNPK 综合评分: 0.357 · 证据 2 条
- TIAL1 综合评分: 0.357 · 证据 1 条
- HNRNPF 综合评分: 0.350 · 证据 2 条
- HNRNPH1 综合评分: 0.350 · 证据 2 条
- HNRNPM 综合评分: 0.350 · 证据 2 条
- MBNL1 综合评分: 0.350 · 证据 2 条
🏥 关联疾病
该基因暂无关联疾病记录