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🧬 基因注释:PRMT5

📝 官方信息

官方名称:protein arginine methyltransferase 5

功能摘要:This gene encodes an enzyme that belongs to the methyltransferase family. The encoded protein catalyzes the transfer of methyl groups to the amino acid arginine, in target proteins that include histones, transcriptional elongation factors and the tumor suppressor p53. This gene plays a role in several cellular processes, including transcriptional regulation, and the assembly of small nuclear ribonucleoproteins. A pseudogene of this gene has been defined on chromosome 4. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015].

🎯 作为靶基因的剪接因子
  • HNRNPH1 综合评分: 0.474 · 证据 2 条
  • RBFOX2 综合评分: 0.460 · 证据 2 条
  • PTBP1 综合评分: 0.444 · 证据 2 条
  • HNRNPA2B1 综合评分: 0.412 · 证据 2 条
  • FUS 综合评分: 0.362 · 证据 1 条
  • Srsf3 综合评分: 0.362 · 证据 1 条
  • fus 综合评分: 0.362 · 证据 1 条
  • HNRNPA1 综合评分: 0.350 · 证据 2 条
  • HNRNPC 综合评分: 0.350 · 证据 2 条
  • MBNL1 综合评分: 0.350 · 证据 2 条
  • Tardbp 综合评分: 0.346 · 证据 1 条
  • HNRNPU 综合评分: 0.300 · 证据 2 条
  • SRSF3 综合评分: 0.300 · 证据 1 条
  • SRSF9 综合评分: 0.300 · 证据 1 条
  • UPF1 综合评分: 0.274 · 证据 1 条
  • PRPF8 综合评分: 0.262 · 证据 1 条
  • Rbmx 综合评分: 0.260 · 证据 1 条
  • RBM10 综合评分: 0.250 · 证据 2 条
  • RBM15 综合评分: 0.250 · 证据 2 条
  • U2af2 综合评分: 0.244 · 证据 1 条
🏥 关联疾病
neurodegenerative disease
低关联 (0.207)
breast cancer
低关联 (0.138)
neoplasm
低关联 (0.135)
hepatocellular carcinoma
低关联 (0.116)
colorectal carcinoma
低关联 (0.116)
lung cancer
低关联 (0.115)
triple-negative breast cancer
低关联 (0.110)
cancer
低关联 (0.108)
prostate cancer
低关联 (0.106)
Miyoshi myopathy
低关联 (0.105)
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