基因注释 - PRMT7

📝 官方信息

官方名称：protein arginine methyltransferase 7

功能摘要：This gene encodes a member of the protein arginine N-methyltransferase family of proteins. The encoded enzyme transfers single methyl groups to arginine residues to generate monomethylarginines on histone proteins as well as other protein substrates. This enzyme plays a role in a wide range of biological processes, including neuronal differentiation, male germ line imprinting, small nuclear ribonucleoprotein biogenesis, and regulation of the Wnt signaling pathway. Mutations in this gene underlie multiple related syndromes in human patients characterized by intellectual disability, short stature and other features. The encoded protein may promote breast cancer cell invasion and metastasis in human patients. [provided by RefSeq, May 2017].

🎯 作为靶基因的剪接因子

HNRNPH1 综合评分: 0.448 · 证据 2 条
RBFOX2 综合评分: 0.444 · 证据 2 条
PTBP1 综合评分: 0.424 · 证据 2 条
HNRNPC 综合评分: 0.412 · 证据 2 条
HNRNPM 综合评分: 0.412 · 证据 2 条
HNRNPA1 综合评分: 0.350 · 证据 2 条
HNRNPA2B1 综合评分: 0.350 · 证据 2 条
MBNL1 综合评分: 0.350 · 证据 2 条
Tardbp 综合评分: 0.336 · 证据 1 条
FUS 综合评分: 0.300 · 证据 1 条
HNRNPK 综合评分: 0.300 · 证据 2 条
HNRNPL 综合评分: 0.300 · 证据 2 条
HNRNPU 综合评分: 0.300 · 证据 2 条
KHSRP 综合评分: 0.300 · 证据 2 条
SRSF9 综合评分: 0.300 · 证据 1 条
fus 综合评分: 0.300 · 证据 1 条
Srsf1 综合评分: 0.274 · 证据 1 条
PRPF8 综合评分: 0.262 · 证据 1 条
EWSR1 综合评分: 0.250 · 证据 2 条
RBM10 综合评分: 0.250 · 证据 2 条

🏥 关联疾病

short stature-brachydactyly-obesity-global developmental delay syndrome

高关联 (0.802)

genetic disorder

中关联 (0.510)

obesity

中关联 (0.490)

brachydactyly

中关联 (0.426)

skeletal dysplasia

中关联 (0.425)

Abnormality of the dentition

中关联 (0.425)

Severe intellectual disability

中关联 (0.425)

Lumbar hyperlordosis

中关联 (0.425)

Abnormal facial shape

中关联 (0.425)

Self-injurious behavior

中关联 (0.425)

🔍 查看该基因的所有关联疾病

🔗 外部数据库链接

NCBI Gene GenBank Ensembl GeneCards UniProt

🧬 基因注释：PRMT7