🧬 基因注释：PTP4A2

官方名称：protein tyrosine phosphatase 4A2

功能摘要：The protein encoded by this gene belongs to a small class of the protein tyrosine phosphatase (PTP) family. PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. PTPs in this class contain a protein tyrosine phosphatase catalytic domain and a characteristic C-terminal prenylation motif. This PTP has been shown to primarily associate with plasmic and endosomal membrane through its C-terminal prenylation. This PTP was found to interact with the beta-subunit of Rab geranylgeranyltransferase II (beta GGT II), and thus may function as a regulator of GGT II activity. Overexpression of this gene in mammalian cells conferred a transformed phenotype, which suggested its role in tumorigenesis. Alternatively spliced transcript variants have been described. Related pseudogenes exist on chromosomes 11, 12 and 17. [provided by RefSeq, Aug 2010].

• Tardbp 综合评分: 0.531 · 证据 1 条
• HNRNPC 综合评分: 0.510 · 证据 2 条
• RBFOX2 综合评分: 0.486 · 证据 2 条
• HNRNPH1 综合评分: 0.474 · 证据 2 条
• FUS 综合评分: 0.424 · 证据 1 条
• fus 综合评分: 0.424 · 证据 1 条
• HNRNPA2B1 综合评分: 0.412 · 证据 2 条
• PTBP1 综合评分: 0.362 · 证据 2 条
• HNRNPA1 综合评分: 0.350 · 证据 2 条
• HNRNPM 综合评分: 0.350 · 证据 2 条
• QKI 综合评分: 0.350 · 证据 1 条
• TIA1 综合评分: 0.348 · 证据 1 条
• ELAVL3 综合评分: 0.342 · 证据 1 条
• CELF2 综合评分: 0.324 · 证据 2 条
• RBM15 综合评分: 0.312 · 证据 2 条
• RBM22 综合评分: 0.312 · 证据 2 条
• UPF1 综合评分: 0.306 · 证据 1 条
• HNRNPD 综合评分: 0.300 · 证据 2 条
• HNRNPL 综合评分: 0.300 · 证据 2 条
• HNRNPU 综合评分: 0.300 · 证据 2 条

该基因暂无关联疾病记录