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🧬 基因注释:RGS10

📝 官方信息

官方名称:regulator of G protein signaling 10

功能摘要:Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 10 belongs to this family. All RGS proteins share a conserved 120-amino acid sequence termed the RGS domain. This protein associates specifically with the activated forms of the two related G-protein subunits, G-alphai3 and G-alphaz but fails to interact with the structurally and functionally distinct G-alpha subunits. Regulator of G protein signaling 10 protein is localized in the nucleus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

🎯 作为靶基因的剪接因子
  • HNRNPA1 综合评分: 0.448 · 证据 2 条
  • HNRNPH1 综合评分: 0.412 · 证据 2 条
  • RBFOX2 综合评分: 0.362 · 证据 2 条
  • HNRNPA2B1 综合评分: 0.350 · 证据 2 条
  • HNRNPC 综合评分: 0.350 · 证据 2 条
  • MBNL1 综合评分: 0.350 · 证据 2 条
  • RBM15 综合评分: 0.250 · 证据 2 条
  • Tardbp 综合评分: 0.248 · 证据 1 条
  • U2af1 综合评分: 0.212 · 证据 1 条
  • U2af2 综合评分: 0.198 · 证据 1 条
  • YBX1 综合评分: 0.198 · 证据 1 条
  • Tra2b 综合评分: 0.162 · 证据 1 条
  • UPF1 综合评分: 0.162 · 证据 1 条
  • CPSF4 综合评分: 0.150 · 证据 2 条
  • CPSF6 综合评分: 0.150 · 证据 2 条
  • CPSF7 综合评分: 0.150 · 证据 2 条
  • CSTF2 综合评分: 0.150 · 证据 2 条
  • DDX5 综合评分: 0.150 · 证据 2 条
  • Srsf1 综合评分: 0.150 · 证据 1 条
  • CPSF1 综合评分: 0.100 · 证据 1 条
🏥 关联疾病

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