🧬 基因注释：RTN3
📝 官方信息
官方名称：reticulon 3
功能摘要：This gene belongs to the reticulon family of highly conserved genes that are preferentially expressed in neuroendocrine tissues. This family of proteins interact with, and modulate the activity of beta-amyloid converting enzyme 1 (BACE1), and the production of amyloid-beta. An increase in the expression of any reticulon protein substantially reduces the production of amyloid-beta, suggesting that reticulon proteins are negative modulators of BACE1 in cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene, and pseudogenes of this gene are located on chromosomes 4 and 12. [provided by RefSeq, May 2012].
🎯 作为靶基因的剪接因子
- Nova2 综合评分: 0.484 · 证据 1 条
- PTBP1 综合评分: 0.444 · 证据 2 条
- MBNL2 综合评分: 0.429 · 证据 1 条
- HNRNPK 综合评分: 0.424 · 证据 2 条
- HNRNPL 综合评分: 0.424 · 证据 2 条
- Srsf3 综合评分: 0.424 · 证据 1 条
- HNRNPA2B1 综合评分: 0.412 · 证据 2 条
- HNRNPC 综合评分: 0.412 · 证据 2 条
- FUS 综合评分: 0.362 · 证据 1 条
- RBFOX2 综合评分: 0.362 · 证据 2 条
- fus 综合评分: 0.362 · 证据 1 条
- Mbnl2 综合评分: 0.360 · 证据 1 条
- PCBP2 综合评分: 0.360 · 证据 1 条
- Ptbp2 综合评分: 0.360 · 证据 1 条
- U2af1 综合评分: 0.356 · 证据 1 条
- HNRNPA1 综合评分: 0.350 · 证据 2 条
- HNRNPH1 综合评分: 0.350 · 证据 2 条
- HNRNPM 综合评分: 0.350 · 证据 2 条
- MBNL1 综合评分: 0.350 · 证据 2 条
- RBM10 综合评分: 0.312 · 证据 2 条
🏥 关联疾病
该基因暂无关联疾病记录