基因注释 - SPEN

📝 官方信息

官方名称：spen family transcriptional repressor

功能摘要：This gene encodes a hormone inducible transcriptional repressor. Repression of transcription by this gene product can occur through interactions with other repressors, by the recruitment of proteins involved in histone deacetylation, or through sequestration of transcriptional activators. The product of this gene contains a carboxy-terminal domain that permits binding to other corepressor proteins. This domain also permits interaction with members of the NuRD complex, a nucleosome remodeling protein complex that contains deacetylase activity. In addition, this repressor contains several RNA recognition motifs that confer binding to a steroid receptor RNA coactivator; this binding can modulate the activity of both liganded and nonliganded steroid receptors. [provided by RefSeq, Jul 2008].

🎯 作为靶基因的剪接因子

HNRNPC 综合评分: 0.536 · 证据 2 条
Tardbp 综合评分: 0.448 · 证据 1 条
HNRNPA1 综合评分: 0.412 · 证据 2 条
QKI 综合评分: 0.412 · 证据 1 条
RBFOX2 综合评分: 0.398 · 证据 2 条
Srsf3 综合评分: 0.398 · 证据 1 条
FUS 综合评分: 0.362 · 证据 1 条
HNRNPK 综合评分: 0.362 · 证据 2 条
SRSF9 综合评分: 0.362 · 证据 1 条
fus 综合评分: 0.362 · 证据 1 条
HNRNPA2B1 综合评分: 0.350 · 证据 2 条
HNRNPF 综合评分: 0.350 · 证据 2 条
HNRNPH1 综合评分: 0.350 · 证据 2 条
HNRNPM 综合评分: 0.350 · 证据 2 条
MBNL1 综合评分: 0.350 · 证据 2 条
TIA1 综合评分: 0.348 · 证据 1 条
HNRNPD 综合评分: 0.300 · 证据 2 条
HNRNPL 综合评分: 0.300 · 证据 2 条
HNRNPU 综合评分: 0.300 · 证据 2 条
KHSRP 综合评分: 0.300 · 证据 2 条

🏥 关联疾病

Radio-Tartaglia syndrome

高关联 (0.752)

neurodegenerative disease

中关联 (0.548)

genetic disorder

中关联 (0.542)

chronic lymphocytic leukemia

中关联 (0.470)

diffuse large B-cell lymphoma

中关联 (0.469)

developmental disorder of mental health

中关联 (0.463)

Neurodevelopmental delay

中关联 (0.407)

melanoma

低关联 (0.378)

colorectal adenocarcinoma

低关联 (0.370)

urinary bladder carcinoma

低关联 (0.370)

🔍 查看该基因的所有关联疾病

🔗 外部数据库链接

NCBI Gene GenBank Ensembl GeneCards UniProt

🧬 基因注释：SPEN