基因注释 - SRSF2

📝 官方信息

官方名称：serine and arginine rich splicing factor 2

功能摘要：The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Two transcript variants encoding the same protein and one non-coding transcript variant have been found for this gene. In addition, a pseudogene of this gene has been found on chromosome 11. [provided by RefSeq, Sep 2010].

🎯 作为靶基因的剪接因子

HNRNPC 综合评分: 0.618 · 证据 2 条
FUS 综合评分: 0.553 · 证据 1 条
fus 综合评分: 0.553 · 证据 1 条
RBFOX2 综合评分: 0.496 · 证据 2 条
TIA1 综合评分: 0.472 · 证据 1 条
HNRNPA2B1 综合评分: 0.448 · 证据 2 条
HNRNPH1 综合评分: 0.448 · 证据 2 条
HNRNPK 综合评分: 0.398 · 证据 2 条
Srsf2 综合评分: 0.398 · 证据 1 条
EWSR1 综合评分: 0.394 · 证据 2 条
HNRNPD 综合评分: 0.362 · 证据 2 条
HNRNPU 综合评分: 0.362 · 证据 2 条
KHSRP 综合评分: 0.362 · 证据 2 条
PTBP1 综合评分: 0.362 · 证据 2 条
SRSF2 综合评分: 0.362 · 证据 1 条
Srsf3 综合评分: 0.362 · 证据 1 条
PCBP2 综合评分: 0.360 · 证据 1 条
HNRNPA1 综合评分: 0.350 · 证据 2 条
HNRNPF 综合评分: 0.350 · 证据 2 条
HNRNPM 综合评分: 0.350 · 证据 2 条

🏥 关联疾病

acute myeloid leukemia

高关联 (0.732)

myelodysplastic syndrome

中关联 (0.682)

hemorrhagic disease

中关联 (0.638)

Sepsis

中关联 (0.637)

chronic myelomonocytic leukemia

中关联 (0.623)

lymphoid neoplasm

中关联 (0.614)

Absence of circulating granulocytes

中关联 (0.605)

neoplasm

中关联 (0.600)

myeloid leukemia

中关联 (0.585)

hematologic disease

中关联 (0.581)

🔍 查看该基因的所有关联疾病

🔗 外部数据库链接

NCBI Gene GenBank Ensembl GeneCards UniProt

🧬 基因注释：SRSF2