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🧬 基因注释:ST6GALNAC4

📝 官方信息

官方名称:ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 4

功能摘要:The protein encoded by this gene is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The encoded protein prefers glycoproteins rather than glycolipids as substrates and shows restricted substrate specificity, utilizing only the trisaccharide sequence Neu5Ac-alpha-2,3-Gal-beta-1,3-GalNAc. In addition, it is involved in the synthesis of ganglioside GD1A from GM1B. The encoded protein is normally found in the Golgi apparatus but can be proteolytically processed to a soluble form. This protein is a member of glycosyltransferase family 29. Transcript variants encoding different isoforms have been found for this gene. Readthrough transcripts exist for this gene and the downstream ST6GALNAC6 gene. [provided by RefSeq, Jan 2022].

🎯 作为靶基因的剪接因子
  • HNRNPA2B1 综合评分: 0.412 · 证据 2 条
  • HNRNPC 综合评分: 0.412 · 证据 2 条
  • HNRNPK 综合评分: 0.398 · 证据 2 条
  • RBM15 综合评分: 0.312 · 证据 2 条
  • TIA1 综合评分: 0.312 · 证据 1 条
  • PTBP1 综合评分: 0.300 · 证据 2 条
  • Srsf1 综合评分: 0.212 · 证据 1 条
  • PCBP2 综合评分: 0.200 · 证据 1 条
  • PRPF8 综合评分: 0.200 · 证据 1 条
  • UPF1 综合评分: 0.198 · 证据 1 条
  • YBX1 综合评分: 0.198 · 证据 1 条
  • Rbmx 综合评分: 0.162 · 证据 1 条
  • AQR 综合评分: 0.150 · 证据 1 条
  • PABPC4 综合评分: 0.150 · 证据 2 条
  • U2af1 综合评分: 0.150 · 证据 1 条
  • EIF4A3 综合评分: 0.100 · 证据 2 条
  • NXF1 综合评分: 0.100 · 证据 1 条
  • Rbm7 综合评分: 0.100 · 证据 1 条
  • Rbpms 综合评分: 0.100 · 证据 1 条
  • Rnps1 综合评分: 0.100 · 证据 1 条
🏥 关联疾病

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