🧬 基因注释：SMG7

官方名称：SMG7 nonsense mediated mRNA decay factor

功能摘要：This gene encodes a protein that is essential for nonsense-mediated mRNA decay (NMD); a process whereby transcripts with premature termination codons are targeted for rapid degradation by a mRNA decay complex. The mRNA decay complex consists, in part, of this protein along with proteins SMG5 and UPF1. The N-terminal domain of this protein is thought to mediate its association with SMG5 or UPF1 while the C-terminal domain interacts with the mRNA decay complex. This protein may therefore couple changes in UPF1 phosphorylation state to the degradation of NMD-candidate transcripts. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Aug 2011].

• HNRNPC 综合评分: 0.510 · 证据 2 条
• HNRNPM 综合评分: 0.474 · 证据 2 条
• PTBP1 综合评分: 0.474 · 证据 2 条
• Tardbp 综合评分: 0.465 · 证据 1 条
• FUS 综合评分: 0.362 · 证据 1 条
• RBFOX2 综合评分: 0.362 · 证据 2 条
• Srsf2 综合评分: 0.362 · 证据 1 条
• Srsf3 综合评分: 0.362 · 证据 1 条
• fus 综合评分: 0.362 · 证据 1 条
• HNRNPA1 综合评分: 0.350 · 证据 2 条
• HNRNPA2B1 综合评分: 0.350 · 证据 2 条
• HNRNPH1 综合评分: 0.350 · 证据 2 条
• MBNL1 综合评分: 0.350 · 证据 2 条
• QKI 综合评分: 0.350 · 证据 1 条
• FUBP1 综合评分: 0.312 · 证据 2 条
• RBM39 综合评分: 0.312 · 证据 2 条
• TIA1 综合评分: 0.312 · 证据 1 条
• Srsf1 综合评分: 0.310 · 证据 1 条
• HNRNPD 综合评分: 0.300 · 证据 2 条
• HNRNPK 综合评分: 0.300 · 证据 2 条

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