SpliceAtlasDB
← 返回基因注释查询

🧬 基因注释:TFIP11

📝 官方信息

官方名称:tuftelin interacting protein 11

功能摘要:This gene encodes a protein component of the spliceosome that promotes the release of the lariat-intron during late-stage splicing through the recruitment of a pre-mRNA splicing factor called DEAH-box helicase 15. The encoded protein contains a G-patch domain, a hallmark of RNA-processing proteins, that binds DEAH-box helicase 15. This protein contains an atypical nuclear localization sequence as well as a nuclear speckle-targeting sequence, enabling it to localize to distinct speckled regions within the cell nucleus. Polymorphisms in this gene are associated with dental caries suggesting a role in amelogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2016].

🎯 作为靶基因的剪接因子
  • HNRNPC 综合评分: 0.510 · 证据 2 条
  • HNRNPA2B1 综合评分: 0.412 · 证据 2 条
  • PRPF8 综合评分: 0.262 · 证据 1 条
  • RBM10 综合评分: 0.250 · 证据 2 条
  • RBM15 综合评分: 0.250 · 证据 2 条
  • RBM39 综合评分: 0.250 · 证据 2 条
  • TIA1 综合评分: 0.250 · 证据 1 条
  • Tardbp 综合评分: 0.212 · 证据 1 条
  • Rnps1 综合评分: 0.198 · 证据 1 条
  • U2af2 综合评分: 0.162 · 证据 1 条
  • UPF1 综合评分: 0.162 · 证据 1 条
  • YBX1 综合评分: 0.162 · 证据 1 条
  • CPSF6 综合评分: 0.150 · 证据 2 条
  • CPSF7 综合评分: 0.150 · 证据 2 条
  • GRSF1 综合评分: 0.150 · 证据 2 条
  • Srsf1 综合评分: 0.150 · 证据 1 条
  • U2af1 综合评分: 0.150 · 证据 1 条
  • EIF4A3 综合评分: 0.100 · 证据 2 条
  • NXF1 综合评分: 0.100 · 证据 1 条
  • RBM20 综合评分: 0.100 · 证据 2 条
🏥 关联疾病
neurodegenerative disease
中关联 (0.487)
malunion fracture
低关联 (0.241)
skin cancer
低关联 (0.240)
🔍 查看该基因的所有关联疾病
🔗 外部数据库链接