🧬 基因注释：TIA1
📝 官方信息
官方名称：TIA1 cytotoxic granule associated RNA binding protein
功能摘要：The product encoded by this gene is a member of a RNA-binding protein family and possesses nucleolytic activity against cytotoxic lymphocyte (CTL) target cells. It has been suggested that this protein may be involved in the induction of apoptosis as it preferentially recognizes poly(A) homopolymers and induces DNA fragmentation in CTL targets. The major granule-associated species is a 15-kDa protein that is thought to be derived from the carboxyl terminus of the 40-kDa product by proteolytic processing. Alternative splicing resulting in different isoforms has been found for this gene. [provided by RefSeq, May 2017].
🎯 作为靶基因的剪接因子
- HNRNPK 综合评分: 0.424 · 证据 2 条
- QKI 综合评分: 0.412 · 证据 1 条
- RBFOX2 综合评分: 0.398 · 证据 2 条
- Tardbp 综合评分: 0.372 · 证据 1 条
- PTBP1 综合评分: 0.362 · 证据 2 条
- HNRNPA1 综合评分: 0.350 · 证据 2 条
- HNRNPA2B1 综合评分: 0.350 · 证据 2 条
- HNRNPC 综合评分: 0.350 · 证据 2 条
- HNRNPM 综合评分: 0.350 · 证据 2 条
- MBNL1 综合评分: 0.350 · 证据 2 条
- RBM22 综合评分: 0.312 · 证据 2 条
- TIA1 综合评分: 0.312 · 证据 1 条
- FUS 综合评分: 0.300 · 证据 1 条
- HNRNPL 综合评分: 0.300 · 证据 2 条
- HNRNPU 综合评分: 0.300 · 证据 2 条
- KHSRP 综合评分: 0.300 · 证据 2 条
- SRSF9 综合评分: 0.300 · 证据 1 条
- fus 综合评分: 0.300 · 证据 1 条
- PRPF8 综合评分: 0.262 · 证据 1 条
- EWSR1 综合评分: 0.250 · 证据 2 条
🏥 关联疾病
amyotrophic lateral sclerosis 26 with or without frontotemporal dementia
中关联 (0.663)
distal myopathy, Welander type
中关联 (0.645)
Abnormality of the skeletal system
中关联 (0.488)
genetic disorder
低关联 (0.187)
neoplasm
低关联 (0.106)