🧬 基因注释：TIE1
📝 官方信息
官方名称：tyrosine kinase with immunoglobulin like and EGF like domains 1
功能摘要：This gene encodes a member of the tyrosine protein kinase family. The encoded protein plays a critical role in angiogenesis and blood vessel stability by inhibiting angiopoietin 1 signaling through the endothelial receptor tyrosine kinase Tie2. Ectodomain cleavage of the encoded protein relieves inhibition of Tie2 and is mediated by multiple factors including vascular endothelial growth factor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011].
🏥 关联疾病
该基因暂无关联疾病记录