🧬 基因注释：TP53

官方名称：tumor protein p53

功能摘要：This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277). [provided by RefSeq, Dec 2016].

• SF1 综合评分: 0.514 · 证据 2 条
• SRSF1 综合评分: 0.464 · 证据 1 条
• Srsf1 综合评分: 0.464 · 证据 1 条
• HNRNPA2B1 综合评分: 0.407 · 证据 2 条
• HNRNPC 综合评分: 0.407 · 证据 2 条
• QKI 综合评分: 0.407 · 证据 1 条
• HNRNPL 综合评分: 0.362 · 证据 2 条
• PCBP2 综合评分: 0.360 · 证据 1 条
• FUS 综合评分: 0.357 · 证据 1 条
• Fus 综合评分: 0.357 · 证据 1 条
• HNRNPK 综合评分: 0.357 · 证据 2 条
• PTBP1 综合评分: 0.357 · 证据 2 条
• SRSF3 综合评分: 0.357 · 证据 1 条
• Srsf3 综合评分: 0.357 · 证据 1 条
• TIAL1 综合评分: 0.357 · 证据 1 条
• fus 综合评分: 0.357 · 证据 1 条
• HNRNPA1 综合评分: 0.350 · 证据 2 条
• HNRNPH1 综合评分: 0.350 · 证据 2 条
• HNRNPM 综合评分: 0.350 · 证据 2 条
• MBNL1 综合评分: 0.350 · 证据 2 条

该基因暂无关联疾病记录