🧬 基因注释：TARDBP
📝 官方信息
官方名称：TAR DNA binding protein
功能摘要：HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene is a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. In addition, this protein regulates alternate splicing of the CFTR gene. A similar pseudogene is present on chromosome 20. [provided by RefSeq, Jul 2008].
🎯 作为靶基因的剪接因子
- HNRNPC 综合评分: 0.494 · 证据 2 条
- HNRNPH1 综合评分: 0.494 · 证据 2 条
- TARDBP 综合评分: 0.479 · 证据 1 条
- Tardbp 综合评分: 0.479 · 证据 1 条
- HNRNPL 综合评分: 0.424 · 证据 2 条
- FUS 综合评分: 0.414 · 证据 1 条
- Fus 综合评分: 0.414 · 证据 1 条
- fus 综合评分: 0.414 · 证据 1 条
- HNRNPA1 综合评分: 0.412 · 证据 2 条
- HNRNPA2B1 综合评分: 0.412 · 证据 2 条
- HNRNPM 综合评分: 0.412 · 证据 2 条
- HNRNPK 综合评分: 0.398 · 证据 2 条
- Srsf3 综合评分: 0.398 · 证据 1 条
- CELF2 综合评分: 0.392 · 证据 2 条
- MBNL1 综合评分: 0.350 · 证据 2 条
- QKI 综合评分: 0.350 · 证据 1 条
- RBM10 综合评分: 0.312 · 证据 2 条
- HNRNPD 综合评分: 0.300 · 证据 2 条
- HNRNPU 综合评分: 0.300 · 证据 2 条
- KHSRP 综合评分: 0.300 · 证据 2 条
🏥 关联疾病
amyotrophic lateral sclerosis
高关联 (0.820)
familial amyotrophic lateral sclerosis
高关联 (0.746)
frontotemporal dementia with motor neuron disease
高关联 (0.705)
frontotemporal dementia
中关联 (0.466)
neurodegenerative disease
中关联 (0.451)
motor neuron disease
中关联 (0.444)
amyotrophic lateral sclerosis, dominant
中关联 (0.413)
genetic disorder
低关联 (0.191)
immunodeficiency due to MASP-2 deficiency
低关联 (0.190)
Parkinson disease
低关联 (0.134)